What is an Exosome?
Exosomes are the most recent generation of bioactive naturally amnion-based products for the treatment of a patient’s hair loss or thinning. They work like paracrine effectors, where they signal or stimulate nearby cells. This stimulating effect on cells and tissues is due to biochemical stimulating contents being transferred from one cell to the next. These messengers are known as microvesicles and exosomes, collectively referred to as extracellular vesicles (EVs).
Exosomes don’t contain any nucleus or DNA and are about 1000 times smaller than regular cells. They are 30-100 nanometer tiny nanoparticles involved in intercellular signaling and cell-to-cell communication. They’re secreted by most body cell types and contain both microRNA (miRNA) and messenger RNA (mRNA).
6 Weeks Later
Clinical images of Exo Treatment by Dr Juliah
6 Weeks Later
What are Exosomes for Hair Loss?
Exosomes for hair restoration have just recently been researched. It wasn’t until 2019 that researchers and doctors decided this treatment had huge potential. Numerous new applications may appear with further clinical trials.
Clinical images courtesy of ExoCoBio & Dr. Iñigo de Felipe
How Exosome Therapy Differs From PRP Injections
Where Does It Come From?
PRP (Platelet Rich Plasma Therapy) treatment uses a person’s own blood which is then prepared to get the platelet-rich concentrate that contains the growth factors.
The effectiveness of the treatment relies greatly on the concentration of the platelets in the patient’s blood. If a patient is unhealthy or has blood-related conditions, the quality of the PRP injections may be affected.
PRP may cause injection site pain, scalp tenderness, itching, and minor irritation. It may also cause swelling and inflammation.
Where Does It Come From?
It’s lab-derived and doesn’t require any blood drawn from the patient. They’re prepared from mesenchymal stem cells and they already come in vials that are ready for injections to the scalp.
Unlike PRP serum, the quality of the exosome injections isn’t affected by the patient’s health, blood volume, or age. During the preparation process, it’s purified to ensure a high concentration of growth factors for treatment success.
Exosome injections may also cause pain at the treated area. However, it won’t trigger any inflammation since it actually contains proteins that regulate the inflammatory response.
Present Delivery Systems
There are two delivery methods currently being researched:
- First is an injection using very fine needle with appropriate depth. Multiple injections are introduced to problematic are to ensure filtration of all the good elements into the scalp to help promoting scalp healing and hair growth.
- Second is another injection, like the first, but instead of being a traditional injection, it almost resembles micro-needling, which is scalp puncturing to enhance hair retention. The needles in this second exosome delivery method are much smaller.
Research shows both micro-needling and injection are viable. Results, however, are favouring micro-needling.
**NO CUTTING, NO EXTENSIVE BLEEDING, NO DOWNTIME, NO EXCESSIVE PAIN COMPARED TO SURGICAL HAIR TRANSPLANT, NO NEED SFOR OCIAL ISOLATION, NO SHAVING NEEDED, MUCH MORE AFFORDABLE**
What Are Mesenchymal Cells?
These are adult stem cells that are isolated from various sources that could differentiate into other cell types. In human beings, these sources are:
- Umbilical cord tissue (Wharton’s Jelly)
- Bone marrow
- Amniotic fluid (a fluid that surrounds a fetus)
- Fat (adipose tissue)
Stromal stem cells or mesenchymal stem cells (MSCs) can differentiate into many cell types within the body, which include:
- Muscle cells
- Bone cells
- Skin cells
- Corneal cells
- Neural cells
Everybody has mesenchymal stem cells. MSCs are mainly found in each person’s bone marrow and stay dormant until they’re called upon for promoting body healing. They age as the individual ages and their effectiveness and number is reduced over the years.
What Is the Exosome Therapy Process?
By nature, regenerative cells work to repair, heal, stimulate and restore tissues and cells. The hair follicle is vulnerable to miniaturization by hormonal and genetic effects from DHT.
The Exosome’s tiny size allows for simple injection into the superficial scalp dermis with local anaesthesia.
By injecting growth factors and exosomes, it’s been clinically shown to help regrow and regenerate hair as a therapy for loss of hair in both women and men in the earlier hair loss stages.
Number of Treatments
Typically, patients should begin seeing the effects within 6 weeks of the first treatment. Many patients with inflammation scalp condition and thinning hair will see substantial improvement after one treatment. Since all patients are different, it’s essential you refer to your doctor for the proper treatment plan that will meet your own individual requirements and to see if you’re a good candidate for Exosome.
What to Expect
Dr Juliah will advise about their exact procedures and protocols in preparation of your Exosome treatment. Most individuals go back to normal day-to-day function post-procedure, but it’s suggested you avoid strenuous exercise right after your procedure to allow the treatment to be successful. Your doctor will talk with you about the post-procedure protocol as well as the proper follow-up.
Are you a Good Candidate?
Exosomes can be used in both early and later hair loss stages. Also, it can be used together with hair transplant or PRP. You may be an ideal candidate for Exosome if:
- You’ve been told you’re not a good candidate for hair transplant
- You’re receding or thinning
- You’re a little hesitant to make a commitment to a hair transplant
- You have female pattern baldness
- If you require an additional treatment after hair transplant or PRP
- You have Traction Alopecia that’s due to thinning (not bald) scalp areas
- You’re a woman with generalized thinning
Post Care Instructions
- No strenuous activity 24hrs post treatment
- May wash scalp/hair after 8-12 hours
- May start applying Minoxidil foam twice a day after washing (8-12hrs post treatment) if not on oral minoxidil.
- Any further queries please contact Dr. Juliah Tbarani O’Shea
Juliah was a pleasure to deal with from start to finish. Very happy with the results and would have no problem recommending her to anybody.
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